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KMID : 0880220100480010040
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Journal of Microbiology
2010 Volume.48 No. 1 p.40 ~ p.43
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Potentiation of Bacterial Killing Activity of Zinc Chloride by Pyrrolidine Dithiocarbamate
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Choi Eun-Kyoung
Lee Hye-Hyang
Kang Mi-Sun
Kim Byung-Gook
Lim Hoi-Soon
Kim Seon-Mi
Kang In-Chol
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Abstract
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Zinc has antimicrobial activity and zinc salts including zinc chloride (ZnCl2) have been used for the control of oral malodor. In this study, we hypothesized that pyrrolidine dithiocarbamate (PDTC), a zinc ionophore, may enhance antimicrobial efficacy of ZnCl2. The bactericidal effectiveness of ZnCl2 alone (0.5-8 mM) or in combination with PDTC (1 or 10 μM) was evaluated by in vitro short (1 h) time-killing assays against Fusobacterium nucleatum and Porphyromonas gingivalis. Only a slight viability decrease was observed with ZnCl2 or PDTC alone after 1-h incubation. By contrast, combination of ZnCl2 and PDTC could achieve a more than 100-fold viability reduction compared with ZnCl2 or PDTC alone in F. nucleatum and P. gingivalis. Therefore, PDTC greatly enhanced the bactericidal activity of ZnCl2 against the oral malodor-producing bacteria. These results suggest that use of PDTC may be useful for enhancing bactericidal activity of antimalodor regimens of zinc salts.
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KEYWORD
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oral malodor, zinc, pyrrolidine dithiocarbamate, bactericidal
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